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ea0089c5 | Clinical – Chemo/SSA/Biologics | NANETS2022

c-MET Expression in MEN1-associated Neuroendocrine Tumors

MD Raisa Ghosh , BS Maya Lee , BS Rana Tora , MGC, CGC James Welch , I Vaishali , BS Parekh , MD Jaydira del Rivero , F William , MD Simonds , MD Lee Scott Weinstein , E Jenny , MD Blau , K Sunita , Ph.D Agarwal , MD Smita Jha

Background: Multiple studies have shown that approximately 50-70% of patients with MEN1 die of causes directly related to MEN1 particularly gastroenteropancreatic (GEP) neuroendocrine tumors (NETs). While non-functional GEP-NETs are the most common in the general population, gastrinomas (40%) are the most common functional GEP-NETs in patients with MEN1. c-Met is a proto-oncogene that encodes for c-MET, a tyrosine kinase receptor which promotes tumor cell motility, proliferati...

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ea0098c50 | Clinical – Surgery/Applied Pathology | NANETS2023

Phenotype Genotype Correlation in Multiple Endocrine Neoplasia Type 1

Worthy Charlita , Vikram Nayan U. , Tora Rana , Welch James , Ninan Anisha , Bliss Lynn , Cochran Craig , S Weinstein Lee , Simonds William F. , Blau Jenny E. , Agarwal Sunita K. , Jha Smita

Background: The presence of a genotype-phenotype correlation in patients with MEN1 remains controversial with conflicting data from different centers. Furthermore, about 10-30% patients have genotype-negative (GN)-MEN1. Here, we evaluate the presence of genotype-phenotype correlation in our cohort of comprehensively phenotyped patients with MEN1. In addition, we compare the phenotype of GN-MEN1 and genotype-positive (GP)-MEN1 patients and investigate somatic mosaicism as a cau...

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Endocrine Abstracts

c-MET Expression in MEN1-associated Neuroendocrine Tumors

Phenotype Genotype Correlation in Multiple Endocrine Neoplasia Type 1

BiosciAbstracts